Scientists were able to protect cells from the effects of high radiation

Ученым удалось защитить клетки от воздействия высокой радиации

The researchers protects the cells of the intestine in the radiation therapy of cancer.

Scientists from the Spanish national centre for cancer research stated that they were able to protect intestinal cells from exposure to radiation therapy of cancer. As reported by Naked science is managed researchers use the protein URI1, reports the with reference to ZN.UA

Radiation therapy is one of the most effective ways to kill cancer cells and reduce metastasis. However, this therapy also destroys healthy cells and leads to dangerous complications approximately 60% of cases. 10% of patients after radiation therapy of a tumor of the intestine develops a gastrointestinal syndrome — a disease characterized by cell death of intestine that leads to the destruction of the entire body and death of the patient.

Now, however, the researchers were able to protect the cells of the intestines due to protein URI1. Its functions are still not fully understood, but previous work it was found that the violation in its production can lead to cancer.

The researchers artificially increased content of this protein in the intestinal cells of mice and found that these cells are less susceptible to high doses of radiation, and therefore, they are characterized by high risk of development of intestinal syndrome.

In the study, researchers created three genetic models of mice. One of them served as a control and to determine where the URI formed in the intestine most often; the other group of mice was artificially created high levels of protein in the intestine, while the third gene was generally removed to reduce the overall level of protein in the body. The researchers then point irradiated intestine of each species doses characteristic of radiotherapy.

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The control group showed that the URI is formed in specific cavities of the intestine from dormant stem cells, which are called Libertyville crypts. In the second group survived 100% of mice, whereas the control lost about 70% of the individuals. In the third group none of the mice failed to survive: all of them died from gastrointestinal syndrome.

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