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Scientists at Tel Aviv University have developed a new method for the treatment of breast cancer, which will significantly increase the effectiveness of chemotherapy, reducing the risk of post-therapeutic lung metastases from 52% to 6%. This was reported by the press service of the university. Scientists have identified the mechanism of formation of the inflammatory environment in response to chemotherapy, which contributes to the development of cancer. They also found that by adding an anti-inflammatory agent to chemotherapy, metastasis can be almost completely prevented. “In many cases of breast cancer, surgical removal of the primary tumor is followed by a chemotherapy regimen designed to kill any remaining malignant cells, both at the surgical site and elsewhere. However, chemotherapy also has unwanted and even harmful side effects, including damage to healthy tissue. Perhaps the most dangerous of these is internal inflammation, which can paradoxically help the remaining cancer cells to metastasize. We wanted to understand how this happens and try to find an effective solution to the problem,” said project leader Prof. Neta Erez from the Pathology Department of the Faculty of Medicine. Scientists have created an animal model of cancer metastasis. Animals received the same treatment as humans. According to the results, metastatic tumors were found in the lungs of a large percentage of the animals. The researchers examined the lungs at an intermediate stage, when tiny micrometastases cannot be identified even with a CT scan. In the end, the scientists combined chemotherapy with a drug that blocks the activity of complementary proteins. After combined treatment, the percentage of animals without metastases increased from 32% to 67%, and the percentage of patients with extensive cancer colonization in the lungs decreased from 52% with regular chemotherapy to 6% with the addition of an inflammation inhibitor.
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