Israeli researchers develop nanotechnology to fight cancer

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 Israeli researchers develop nanotechnology to fight cancer

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Researchers at Bar Ilan University have developed a new technology that uses nanoparticles to help the body's immune system fight cancer.

According to a study published in the journal EMBO Molecular Medicine, Nanoparticles are used to remove obstacles around a malignant tumor that interfere with the normal activity of lymphocytes.

Lymphocytes are the body's powerful defense weapons that help the immune system fight viral infections, tumor growth, and the spread of cancerous metastases. Researchers know that lymphocytes have an important potential for cancer treatment by immunotherapy, because under certain circumstances they can easily and effectively kill cancer cells. tumors. However, despite their great promise, researchers and physicians find it difficult to use them for immunotherapy.

Moreover, no clinical trial conducted to date has demonstrated the superiority of lymphocyte-based treatments. This is because the tumor microenvironment usually activates inhibitory mechanisms that suppress lymphocyte activity.

To overcome these obstacles, Prof. Mira Barda-Saad and her collaborators from the Faculty of Life Sciences Bar-Ilana Mina and Everard Goodman developed a mechanism for incorporating lipid-based nanoparticles into lymphocytes. This procedure “packs” RNA molecules into the lipid membrane, and after penetration they interfere with the expression of the gene responsible for the inactivation of lymphocytes.

tumor mass. The significance of this innovation lies in the fact that this new nanotechnological mechanism can be very effective in applying already established medical approaches based on lymphocytes, as well as other methods of treatment.

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