Scientists have found a new way to detect cancerous tumors that will allow sick people to suffer less from chemistry
Experts at Purdue University have developed technology that enables the location of the cancer in the body will be determined more accurately, which will increase the effectiveness of treatment and reduce the painful side effects of chemotherapy.
One of the major problems of chemotherapy is that most treatment methods focus on the tumor itself, without paying due attention to the surrounding microenvironment. A new method is described in detail in the journal Small, devoted to nanotechnology.
“The traditional method of treatment can be likened to a situation when the driver has to deliver a package, but unknown to him the address of the client. Our approach allows us to detect the “address” and deliver “cargo” is a chemotherapeutic drug,” says Yoon Yeo, Professor, Department of General and industrial pharmacology at Purdue, head of the research team.
The centers for prevention and disease control report that in the United States each year, about 650 thousand cancer patients undergoing chemotherapy in outpatient Oncology clinics. Chemotherapy usually involves a risk of various side effects that can lead to hospitalization, disrupting the treatment, and even death.
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The method, developed at Purdue, is based on the use in chemotherapy of nanoparticle carriers of drugs acting on the tumor. Experts have developed a method to create a polyol-modified nanoparticles that can identify the location of cancer cells and tumours as located next to blood vessels.
The nanoparticles interact with the walls of the blood vessels penetrating into the tumor and destroying it. Scientists from Purdue argue that their method allows the nanoparticles to stroyraboty in krovopotere and finding the tumor, to penetrate it, which increases the effectiveness of treatment. The method has been tested in models of breast cancer and melanoma. Experts believe that he will perform well in treating other cancers.
“For most patients chemotherapy is an infernal flour. We want to change that, says Yeo. — Our method allows to accurately determine the location of the tumor, so that treatment will need smaller doses of drugs and, therefore, less affected healthy tissue”.
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